Transthyretin Blocks Retinol Uptake and Cell Signaling by the Holo-Retinol-Binding Protein Receptor STRA6
نویسندگان
چکیده
منابع مشابه
Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation.
Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP). At some tissues, RBP is recognized by STRA6, a plasma membrane protein that serves a dual role: it transports retinol from extracellular RBP into cells and it transduces a signaling cascade mediated by the Janus kinase JAK2 and the transcription factors STAT3 and STAT5. We show here that expression of RBP and STRA6 ...
متن کاملCross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6.
The plasma membrane protein STRA6 transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling. We show here that, unlike other cytokine receptors, phosphorylation of STRA6 is not simply induced upon binding of its extracellular ligand. Instead, activation of the receptor is triggered by STR...
متن کاملMatthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6.
Retinoic acid (RA) is a potent teratogen in all vertebrates when tight homeostatic controls on its endogenous dose, location, or timing are perturbed during early embryogenesis. STRA6 encodes an integral cell-membrane protein that favors RA uptake from soluble retinol-binding protein; its transcription is directly regulated by RA levels. Molecular analysis of STRA6 was undertaken in two human f...
متن کاملUptake of retinol and retinoic acid from serum retinol-binding protein by retinal pigment epithelial cells.
Isolated pigment epithelial cells from bovine eyes were shown to be capable of taking up retinol and retinoic acid. The uptake was dependent on the ligands being presented to the cells as complexes with serum retinol-binding protein. Neither free retinol nor retinol or retinoic acid presented as serum albumin complexes were taken up by the pigment epithelial cells. The transport of retinal and ...
متن کاملReal-time analyses of retinol transport by the membrane receptor of plasma retinol binding protein.
Vitamin A is essential for vision and the growth/differentiation of almost all human organs. Plasma retinol binding protein (RBP) is the principle and specific carrier of vitamin A in the blood. Here we describe an optimized technique to produce and purify holo-RBP and two real-time monitoring techniques to study the transport of vitamin A by the high-affinity RBP receptor STRA6. The first tech...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2012
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00775-12